Irreversible reaction

Grignard formation from magnesium and methyl bromide

Mg+CH3BrCH3BrMg

Direction
Irreversible
Processes
1
Stated as
Rate law
Heat of reaction
ΔH = -291,100 kJ/kmol (one process)
Element balance
Checked: balances
As the processes state itStoichiometry, conversions, heats of reaction and catalyst windows are taken from each process's files with their provenance. The build checks only that each process's equation balances in every element, from the process's own component formulas; it does not check the numbers. A process's design maturity applies to them.

Species

SpeciesNameCASRoleCoefficient
MgMagnesium7439-95-4reactant-1
CH3BrBromomethane (methyl bromide)74-83-9reactant-1
CH3BrMgMethylmagnesium bromide75-16-1product1

In the processes

  • Methylmagnesium bromide in 2-MeTHF by semi-batch Grignard reaction with methyl bromide gas dosing (4400 t/a)Concept · not reviewed

    GRIG · Grignard formation from magnesium and methyl bromideMg + CH3Br → CH3MgBr

    Stated as
    Rate law
    Phase
    liquid
    Element balance
    Balances in every element
    Heat of reaction
    ΔH = -291,100 kJ/kmol at 298.15 K, as written (given: Holm (1981), J. Chem. Soc. Perkin Trans. 2, 464, via the NIST WebBook (CID C75161, reaction thermochemistry): -267.8 +/- 4.4 kJ/mol for Mg(cr) + CH3Br(l) in diethyl ether, less the heat of vaporisation of methyl bromide at 298 K, 23.3 kJ/mol (thermo): the dosed gas's basis (D-005))
    Rate law
    basis: volume; driving: concentration; form: power_law; k: {"A":"7.389e4","Ea":40000}; orders: {"MEBR":1,"MG":0.6667}; temperature range: 298.15 – 338.15 (assumed: ASSUMED fast effective rate of the initiated reaction (D-005): no open kinetics found (2026-11-05); to be replaced by reaction calorimetry (heat flow and in-situ IR during the dosing))

Sources

What the processes cite for this reaction, each source once: for the reaction itself, its conversion, its heat of reaction or its catalyst. As the processes write them; DOIs, US patent numbers and web addresses are linked.

  1. HSDB via PubChem CID 6349 (Methods of Manufacturing)

    For the reaction · cited by Methylmagnesium bromide in 2-MeTHF by semi-batch Grignard reaction with methyl bromide gas dosing (4400 t/a)

  2. Holm 1981 via the NIST WebBook (heat of reaction)

    For the reaction · cited by Methylmagnesium bromide in 2-MeTHF by semi-batch Grignard reaction with methyl bromide gas dosing (4400 t/a)

  3. Holm (1981), J. Chem. Soc. Perkin Trans. 2, 464, via the NIST WebBook (CID C75161, reaction thermochemistry): -267.8 +/- 4.4 kJ/mol for Mg(cr) + CH3Br(l) in diethyl ether, less the heat of vaporisation of methyl bromide at 298 K, 23.3 kJ/mol (thermo): the dosed gas's basis (D-005)

    For the heat of reaction · cited by Methylmagnesium bromide in 2-MeTHF by semi-batch Grignard reaction with methyl bromide gas dosing (4400 t/a)